A Central Role for P48/45 in Malaria Parasite Male Gamete Fertility

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A Central Role for P48/45 in Malaria Parasite Male Gamete Fertility

Fertilization and zygote development are obligate features of the malaria parasite life cycle and occur during parasite transmission to mosquitoes. The surface protein PFS48/45 is expressed by male and female gametes of Plasmodium falciparum and PFS48/45 antibodies prevent zygote development and transmission. Here, gene disruption was used to show that Pfs48/45 and the ortholog Pbs48/45 from a ...

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ژورنال

عنوان ژورنال: Cell

سال: 2001

ISSN: 0092-8674

DOI: 10.1016/s0092-8674(01)00199-4